Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress
J Li, NJ Holbrook - Experimental gerontology, 2004 - Elsevier
The endoplasmic reticulum (ER), as a processing plant for the folding and posttranslational
modification of proteins, is exquisitely sensitive to changes in its internal environment.
Various conditions, collectively termed 'ER stress', can perturb ER functions, leading to the
activation of a complex response known as the unfolded protein response. Here, we
investigated the response of hepatocytes derived from young (4–5 months) and aged (24–
26 months) rats to two agents, thapsigargin (TG) and tunicamycin (TM), which act via …
modification of proteins, is exquisitely sensitive to changes in its internal environment.
Various conditions, collectively termed 'ER stress', can perturb ER functions, leading to the
activation of a complex response known as the unfolded protein response. Here, we
investigated the response of hepatocytes derived from young (4–5 months) and aged (24–
26 months) rats to two agents, thapsigargin (TG) and tunicamycin (TM), which act via …
