Proteome profiling of recombinant DNase therapy in reducing NETs and aiding recovery in COVID-19 patients
Severe coronavirus disease 2019 (COVID-19) can result in pneumonia and acute
respiratory failure. Accumulation of mucus in the airways is a hallmark of the disease and
can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum
from severe patients with COVID-19 reveal high levels of neutrophil extracellular trap (NET)
components, which was confirmed by microscopy. Extracellular DNA from excessive NET
formation can increase sputum viscosity and lead to acute respiratory distress syndrome …
respiratory failure. Accumulation of mucus in the airways is a hallmark of the disease and
can result in hypoxemia. Here, we show that quantitative proteome analysis of the sputum
from severe patients with COVID-19 reveal high levels of neutrophil extracellular trap (NET)
components, which was confirmed by microscopy. Extracellular DNA from excessive NET
formation can increase sputum viscosity and lead to acute respiratory distress syndrome …
